Research

2R01MH068721 Ranganath, PI
NIMH
April 25, 2010 – March 31, 2015

For this project, we are using fMRI and EEG to understand the neural mechanisms of memory for temporal information. We are investigating both working memory processes that allow us to maintain an online representation of temporal sequences and episodic memory processes that allow us to remember the temporal context of an event. Our studies have indicated that regions in the prefrontal cortex play a critical role in these processes, and they indicate that frontal theta oscillations play a role in successful maintenance of temporal order information.

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1R01MH084895-01 Ragland, PI
NIMH
April 1, 2010-March 31, 2014

Brain Mechanisms of Impaired Episodic Memory in Schizophrenia

In this project, we are using fMRI and eye-tracking methods to investigate memory deficits in schizophrenia. Episodic memory is significantly impaired in schizophrenia, and current medications do not have any significant effect on these deficits. Furthermore, episodic memory is among the most reliable predictors of whether a patient will be able to return to work and live independently. Our research suggests that episodic memory deficits in schizophrenia patients may be related, in part, to dysfunction of the dorsolateral prefrontal cortex. We are working to further test this hypothesis and develop cognitive training methods to help improve prefrontal functioning in these patients.

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1R01MH083734-01 Ranganath & Yonelinas, joint PIs
NIMH
December 10, 2008-November 30, 2013

3R01MH083734-S1 (Ranganath PI)
NIMH
October 1, 2009-September 30, 2011

Perirhinal cortex and associative memory

The goals of this project are to use functional imaging and behavioral studies to test three theories regarding the role of perirhinal cortex in processes that support associative memory. In 2009, received an ARRA-funded supplement from NIMH to investigate familiarity-based associative recognition and perirhinal cortex functioning in schizophrenia.

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1R01MH084826-01 (Carter, PI)
NIMH
November 1, 2008-September 30, 2013

Cognitive Neuroscience Task Reliability & Clinical Applications (CNTRACs) Consortium

This project aims to develop versions of tasks that are typically used to assess visual perception, attention, cognitive control, and episodic memory in basic cognitive neuroscience research so that they may be used to assess cognitive functioning in patients with schizophrenia. Our work has already shown that associative memory is the single most reliable measure in discriminating between schizophrenia patients and healthy subjects. In 2010, we received an ARRA-funded supplement from NIMH to use functional imaging to identify biomarkers for cognitive deficits in schizophrenia.

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1R24MH081807-01 (Carter, PI; Ranganath & Ragland, project PIs)
NIMH
September 30, 2008-September 29, 2011

Cognitive Control in Schizophrenia

The goals of this project are to build collaborations between experts on the neuroscience of attention, memory, language and emotional processing, processes that are impaired in schizophrenia.
Role: Project PI

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Larry L. Hillblom Foundation Network Grant (DeCarli, PI)
$2,000,000 Direct Costs
July 1, 2008-June 30, 2010

The goal of this project is to establish a research network that will use comprehensive behavioral assessments, cognitive electrophysiology, and structural and functional imaging to examine the effects of diabetes and normal aging on brain function related to memory.
Role: Co-investigator

Projects