Research
PAST PROJECTS
NSSEFF (OFFICE OF NAVAL RESEARCH/DEPARTMENT OF DEFENSE)
Ranganath, PI
February 01, 2015 – January 30, 2019
Decoding and Enhancing Neural Mechanisms for Episodic Memory
The goal of this project is to determine the causal role for theta oscillations in episodic memory. Three methods are proposed—transcranial alternating current stimulation, sensory entrainment, and reward motivation—to manipulate theta activity and determine the effects on memory for contextual details and corresponding effects on brain activity measured by fMRI and EEG.
Role: Principal Investigator
Ranganath, PI
February 01, 2015 – January 30, 2019
Decoding and Enhancing Neural Mechanisms for Episodic Memory
The goal of this project is to determine the causal role for theta oscillations in episodic memory. Three methods are proposed—transcranial alternating current stimulation, sensory entrainment, and reward motivation—to manipulate theta activity and determine the effects on memory for contextual details and corresponding effects on brain activity measured by fMRI and EEG.
Role: Principal Investigator
BEHAVIORAL HEALTH CENTER OF EXCELLENCE PILOT AWARD
Antzloulatos & Ranganath, PIs
April 01, 2015 – March 31, 2017
A translational approach to development of electrical brain stimulation for cognitive enhancement
The goal of this project is to develop a monkey model of tDCS in order to clarify how tDCS affects activity and synchrony of neural populations, and to validate noninvasive biomarkers of tDCS effects for use in human studies.
Role: co-Principal Investigator
Antzloulatos & Ranganath, PIs
April 01, 2015 – March 31, 2017
A translational approach to development of electrical brain stimulation for cognitive enhancement
The goal of this project is to develop a monkey model of tDCS in order to clarify how tDCS affects activity and synchrony of neural populations, and to validate noninvasive biomarkers of tDCS effects for use in human studies.
Role: co-Principal Investigator
BEHAVIORAL HEALTH CENTER OF EXCELLENCE PILOT AWARD
Ranganath, PI
April 01, 2015 – March 31, 2017
Individualized tACS to enhance oscillatory activity and cognitive performance in patients with schizophrenia
The goal of this pilot project is to assess the feasibility of tACS as a method to enhance cognition in patients with schizophrenia.
Role: Principal Investigator
Ranganath, PI
April 01, 2015 – March 31, 2017
Individualized tACS to enhance oscillatory activity and cognitive performance in patients with schizophrenia
The goal of this pilot project is to assess the feasibility of tACS as a method to enhance cognition in patients with schizophrenia.
Role: Principal Investigator
1R01NS076856 (NINDS)
Ekstrom, PI
July 01, 2012 – June 30, 2017
Representation and binding of spatiotemporal episodic memories in the human hippocampus
This project investigates how the human hippocampus represents space and time in episodic memory.
Role: Co-Investigator
Ekstrom, PI
July 01, 2012 – June 30, 2017
Representation and binding of spatiotemporal episodic memories in the human hippocampus
This project investigates how the human hippocampus represents space and time in episodic memory.
Role: Co-Investigator
2R01MH068721 (NIMH)
Ranganath, PI
April 25, 2010 – March 31, 2015
For this project, we are using fMRI and EEG to understand the neural mechanisms of memory for temporal information. We are investigating both working memory processes that allow us to maintain an online representation of temporal sequences and episodic memory processes that allow us to remember the temporal context of an event. Our studies have indicated that regions in the prefrontal cortex play a critical role in these processes, and they indicate that frontal theta oscillations play a role in successful maintenance of temporal order information.
Ranganath, PI
April 25, 2010 – March 31, 2015
For this project, we are using fMRI and EEG to understand the neural mechanisms of memory for temporal information. We are investigating both working memory processes that allow us to maintain an online representation of temporal sequences and episodic memory processes that allow us to remember the temporal context of an event. Our studies have indicated that regions in the prefrontal cortex play a critical role in these processes, and they indicate that frontal theta oscillations play a role in successful maintenance of temporal order information.
1R01MH084895-01 (NIMH)
Ragland, PI
April 1, 2010-March 31, 2014
Brain mechanisms of impaired episodic memory in schizophrenia
In this project, we are using fMRI and eye-tracking methods to investigate memory deficits in schizophrenia. Episodic memory is significantly impaired in schizophrenia, and current medications do not have any significant effect on these deficits. Furthermore, episodic memory is among the most reliable predictors of whether a patient will be able to return to work and live independently. Our research suggests that episodic memory deficits in schizophrenia patients may be related, in part, to dysfunction of the dorsolateral prefrontal cortex. We are working to further test this hypothesis and develop cognitive training methods to help improve prefrontal functioning in these patients.
Ragland, PI
April 1, 2010-March 31, 2014
Brain mechanisms of impaired episodic memory in schizophrenia
In this project, we are using fMRI and eye-tracking methods to investigate memory deficits in schizophrenia. Episodic memory is significantly impaired in schizophrenia, and current medications do not have any significant effect on these deficits. Furthermore, episodic memory is among the most reliable predictors of whether a patient will be able to return to work and live independently. Our research suggests that episodic memory deficits in schizophrenia patients may be related, in part, to dysfunction of the dorsolateral prefrontal cortex. We are working to further test this hypothesis and develop cognitive training methods to help improve prefrontal functioning in these patients.
1R01MH083734-01 (NIMH)
Ranganath & Yonelinas, PIs
December 10, 2008-November 30, 2013
3R01MH083734-S1 (NIMH)
Ranganath PI
October 1, 2009-September 30, 2011
Perirhinal cortex and associative memory
The goals of this project are to use functional imaging and behavioral studies to test three theories regarding the role of perirhinal cortex in processes that support associative memory. In 2009, received an ARRA-funded supplement from NIMH to investigate familiarity-based associative recognition and perirhinal cortex functioning in schizophrenia.
Ranganath & Yonelinas, PIs
December 10, 2008-November 30, 2013
3R01MH083734-S1 (NIMH)
Ranganath PI
October 1, 2009-September 30, 2011
Perirhinal cortex and associative memory
The goals of this project are to use functional imaging and behavioral studies to test three theories regarding the role of perirhinal cortex in processes that support associative memory. In 2009, received an ARRA-funded supplement from NIMH to investigate familiarity-based associative recognition and perirhinal cortex functioning in schizophrenia.
1R01MH084826-01 (NIMH)
Carter, PI
November 1, 2008-September 30, 2013
Cognitive Neuroscience Task Reliability & Clinical Applications (CNTRACs) Consortium
This project aims to develop versions of tasks that are typically used to assess visual perception, attention, cognitive control, and episodic memory in basic cognitive neuroscience research so that they may be used to assess cognitive functioning in patients with schizophrenia. Our work has already shown that associative memory is the single most reliable measure in discriminating between schizophrenia patients and healthy subjects. In 2010, we received an ARRA-funded supplement from NIMH to use functional imaging to identify biomarkers for cognitive deficits in schizophrenia.
Carter, PI
November 1, 2008-September 30, 2013
Cognitive Neuroscience Task Reliability & Clinical Applications (CNTRACs) Consortium
This project aims to develop versions of tasks that are typically used to assess visual perception, attention, cognitive control, and episodic memory in basic cognitive neuroscience research so that they may be used to assess cognitive functioning in patients with schizophrenia. Our work has already shown that associative memory is the single most reliable measure in discriminating between schizophrenia patients and healthy subjects. In 2010, we received an ARRA-funded supplement from NIMH to use functional imaging to identify biomarkers for cognitive deficits in schizophrenia.
1R24MH081807-01 (NIMH)
Carter, PI; Ranganath & Ragland, project PIs
September 30, 2008-September 29, 2011
Cognitive Control in Schizophrenia
The goals of this project are to build collaborations between experts on the neuroscience of attention, memory, language and emotional processing, processes that are impaired in schizophrenia.
Role: Project PI
Carter, PI; Ranganath & Ragland, project PIs
September 30, 2008-September 29, 2011
Cognitive Control in Schizophrenia
The goals of this project are to build collaborations between experts on the neuroscience of attention, memory, language and emotional processing, processes that are impaired in schizophrenia.
Role: Project PI
LARRY L. HILLBLOM FOUNDATION NETWORK GRANT ($2,000,000 DIRECT COSTS)
DeCarli, PI
July 1, 2008-June 30, 2010
The goal of this project is to establish a research network that will use comprehensive behavioral assessments, cognitive electrophysiology, and structural and functional imaging to examine the effects of diabetes and normal aging on brain function related to memory.
Role: Co-investigator
DeCarli, PI
July 1, 2008-June 30, 2010
The goal of this project is to establish a research network that will use comprehensive behavioral assessments, cognitive electrophysiology, and structural and functional imaging to examine the effects of diabetes and normal aging on brain function related to memory.
Role: Co-investigator
